SqualVax Adjuvants Cover Image
SqualVax Adjuvants Profile Picture
SqualVax Adjuvants
@SqualVax_Adjuvants • 0 people like this
SqualVax Adjuvants has not posted anything yet

SqualVax is an oil-in-water emulsion made of squalene droplets in a continuous aqueous phase. It is fully biodegradable, which is an important advantage over alternative oils that have been used in emulsion adjuvants, like Freund's adjuvant that contains mineral oil (paraffin oil) and has long term persistence in the organisms. Squalene emulsion induces local stimulation and recruitment of DCs and granulocytes, differentiation of monocytes into DCs and increased uptake of antigen by DCs. The emulsion acts more specifically on macrophages present at the site of injection. A local increase of chemokines released also influences the recruitment of immune cells from the blood to the site of vaccination, creating an amplification loop. This formulation enhances differentiation of monocytes towards a mature phenotype, thereby promoting migration of antigen-loaded cells to the draining lymph node. Compared to aluminium salts, a stronger immune response is elicited (e.g higher antibody “h